We wondered whether this striking rescue might be caused, at least in part, by improvements in axonal transport
," explained Dr.
Uptake and retrograde axonal transport
of various exogenous macromolecules in normal and crushed hypoglossal nerves.
The results demonstrate that the axonal transport
of cargo proteins is impaired in preclinical models of ALS and Parkinson's disease and correlates with disease severity.
Sirus is applying its proprietary polymer expertise and Axonal Transport
Technology to a proprietary GSK analgesic compound.
KineMed's techniques have also been applied to investigate other pathways such as microtubule dynamics, mitochondrial turnover and axonal transport
which are involved in HD and other neurodegenerative diseases.
Brady and his colleagues began looking for a mechanism that could solve the puzzle, and found that at extremely low concentrations, huntingtin was a potent inhibitor of axonal transport
, the system within the neuron that shuttles proteins from the cell body where they are synthesized to the synaptic terminals where they are needed.
Our compelling axonal transport
data, using samples from human cerebrospinal fluid, puts into the hands of scientists and doctors a tool to measure the impact of treatments for Parkinson's disease.
Based on that discovery, the combined research team defined that the mutations in the Dnchc1 gene impaired axonal transport
in the nerve cell, which specifically caused cell-death in motor neurons without affecting other cell types.