Importantly, kinesin motor-mediated axonal transport
is impaired in AD, where p-tau is reported to impair kinesin-dependent axonal cargo trafficking by blocking transport of the adaptor-molecule c-Jun N-terminal kinase interacting protein 1 from the cell body to axons.
Mini-Review: Impaired Axonal Transport
Saxton, "The axonal transport
of mitochondria," Journal of Cell Science, vol.
Mechanisms of the inhibition of fast axonal transport
by local anesthetics.
KineMed's neurodegeneration biomarker of axonal transport
deficit has been recently published in the Journal of Clinical Investigation(1) and validated in patients with other neurological disorders.
In particular, compression of the nerve roots can disrupt their axonal transport
, resulting in increased susceptibility of the distant segments of the nerve to external stimuli, including mechanical compression [1,2].
We hypothesized that the axonal transport
of substances in old and young rats is unlike to the axonal transport
in adult rats.
Omitted are areas such as the immune system, axonal transport
, pharmacokinetics, compartmental modeling, wound healing and tumor modeling.
Many aspects of the action potential, synaptic transmission, and fast axonal transport
have been worked out in detail in the squid (Young, 1939; Bulloch, 1948; Bloedel et al, 1966; Katz and Miledi, 1967; Kusano et al.
Polyglutamines stop traffic: axonal transport
as a common target in neurodegenerative diseases.
2002) demonstrated that NEFL mutant neurofilaments assembly and their axonal transport
in mammalian cells and neurons is disrupted.
Spread of the virus to and from the nerve ganglia occurs by axonal transport
, which has been demonstrated for B virus in experimentally infected mice (7).