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Anticonvulsants: Barbituates such as phenobarbital or Mysoline[R] (primidone) alter the metabolism of vitamin D.
The animals were euthanized by overdose of barbituates and the four thoracic limbs were shipped frozen from Corvallis, OR to Columbia, MO.
This, coupled with the lack of adverse effects that were frequently observed in patients taking barbituates, soon led to clinical utility and acceptance.
A HOLLYWOOD'S most charming cad was 65 when he took a fatal overdose of barbituates in the coastal town of Castelldefels, near Barcelona, in 1972.