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Blast crisis is only used to describe hyperleukocytosis in CML.
Blast crisis (BC) phase was defined as peripheral blood blasts > 20% of peripheral blood white blood cells or nucleated bone marrow cells; extra medullary blast proliferation; and large foci or clusters of blasts on bone marrow biopsy.
Patient with accelerated or blast crisis the efficacy of imatinib is poor.
The presence of trisomy 19 as a new finding in a patient with a known diagnosis of CML is usually seen in patients with accelerated or blast crisis of CML.
Of clinical importance, they noted that sabutoclax, which suppresses all BCL2 anti-apoptotic proteins, renders these marrow-dwelling blast crisis LSCs sensitive-and more susceptible-to TKI-based therapeutics at doses that do not harm normal progenitor cells.
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.
Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia.
The cells soon fill the bone marrow and spill into the bloodstream, a tell-tale sign that the disease has advanced to the blast crisis stage.
Its occurrence usually signifies the transition from the chronic phase of CML into an accelerated phase or, at worst, into a blast crisis.
9/L --> 15% blasts in peripheral blood --> 20% basophils and eosinophils in peripheral blood Blast Crisis Phase * > 30% blasts and promyelocytes exist in peripheral blood or marrow.
Oliver Ottman, of the Johann Wolfgang Goethe Universitat in Frankfurt-am-Main, Germany, and his colleagues conducted an open-label, phase II study to evaluate the efficacy of nilotinib in patients with imatinib-resistant or -intolerant CML in blast crisis (CML-BC) or relapsed/refractory Ph+ ALL.