CBZ acts more specifically on the stiffening of blood-testis barrier
junctions, impacting on germ cell migration, whereas IPR is more deleterious to meiosis.
In these tubules, it appeared that the reorganization of the seminiferous epithelium began in the tubular periphery, with Sustentocytes cells and spermatogonia (stem cells) resting on the basement membrane, and the reestablishment of the blood-testis barrier
Cadmium also disrupts the blood-testis barrier
by making changes in the tight junction and Fak that are complex regulators of occluding-zo1 (18-20).
NC1 domain of collagen a3(IV) derived from the basement membrane regulates Sertoli cell blood-testis barrier
dynamics," Spermatogenesis 3(2): e25465.
It is possible that these Sertoli cell lesions lead to a disruption of the blood-testis barrier
, allowing the subsequent passage of antigens from the tubular lumen to the testicular interstitium.
Interleukin-1alpha is a regulator of the blood-testis barrier
," FASEB Journal 25(4): 1244-1253.
Sertoli cells also constitute the blood-testis barrier
Restricted Arp3 expression in the testis prevents blood-testis barrier
disruption during junction restructuring at spermatogenesis," Proceedings of the National Academy of Sciences of the United States of America 107(25): 11411-11416.
Disruption of the blood-testis barrier
integrity by bisphenol A in vitro: Is this a suitable model for studying blood-testis barrier
Epidermal growth factor receptor pathway substrate 8 (Eps8) is a novel regulator of cell adhesion and the blood-testis barrier
integrity in the seminiferous epithelium," FASEB Journal 23(8): 2555-2567.
Interleukin 1 Alpha (IL1A) is a novel regulator of the blood-testis barrier
in the rat," Biology of Reproduction 78(3): 445-454.
Disruption of Sertoli-germ cell adhesion function in the seminiferous epithelium of the rat testis can be limited to adherens junctions without affecting the blood-testis barrier
integrity: An in vivo study using an androgen suppression model," Journal of Cellular Physiology 205(1): 141-157.