Constipation is passage of small amounts of hard, dry bowel movements
, usually fewer than three times a week.
This protects the skin by sealing out moisture and the irritants within bowel movements
Before the waste material reaches the rectum, most of the water may be gone, causing hard, dry bowel movements
Patients with CIC often experience hard stools, straining during bowel movements
and not enough bowel movements
during the week.
Symptoms of constipation include hard stools, straining to have a bowel movement
, abdominal pain, nausea and bloating.
Reportedly, at the end of the study the group given Lactobacillus reuteri Protectis had significantly more bowel movements
per week than the group given placebo.
After a month, babies who took the probiotic showed a significant decrease in crying time and a rise in frequency of bowel movements
The trial was designed to measure clinical response, defined as the number of patients who had two or fewer watery bowel movements
Linaclotide was more effective in reducing abdominal pain and increasing the number of complete spontaneous bowel movements
, compared with placebo, in both trials.
In both trials and at both doses, linaclotide-treated patients also had significantly greater improvements than did the placebo patients on all secondary end points, including changes in bowel symptoms (the number of weekly CSBMs and spontaneous bowel movements
, stool consistency, and straining severity), abdominal symptoms (discomfort and bloating), and constipation severity.
Comment: This study indicates that the probiotic strain Lactobacillus reuteri (DSM 17938) increased the frequency of bowel movements
in infants with functional chronic constipation.
Respondents were asked about bowel frequency, stool consistency, painful bowel movements
, chronic constipation, and soiling, he said at the meeting, which was hosted by the American Neurogastroenterology and Motility Society.