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This indifference was taken to its logical extremes by the British empiricists and the Circle of Vienna, to the point that epistemological anarchy would eventually fill the void left by the collapsed edifice of logical positivism.
Gassendi clearly stands at the threshold of modernity, anticipating the British empiricists by more than a century.
The question undergoes a shift with the British empiricists, and it is Locke's redefinition of clarity and distinctness (Essay, II, XXIX, 6) which in effect brings about this shift: the concern with the reality of knowledge comes to be supplanted by the concern with the meaningfulness of the language expressing it, and ironically enough, claims about God--and hence, Descartes's requirement for perfect knowledge--are dismissed as meaningless.

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