Logistic regression analysis showed that misclassification of treatment failure was more likely if the patient had a higher CD4 count, a shorter duration of treatment and a smaller decline in CD4 cell
Attempts at solving this problem resulted in the first proposal of criteria for diagnosis of IRD5, which include, in addition to precise clinical findings, success of HAART, where virological success is considered a major criterion & an increased blood CD4 cell
count a minor criterion.
Dr Mathai added: Normal values for CD4 cells
are 500-1200 cells/mm3.
If AZT is associated with an impaired CD4 cell
count, it could mean that some people are changing their treatment unnecessarily.
In patients with low CD4 cell
counts (200 cells/mcL or fewer), treatment with ART was linked with a reduced rate of hepatic failure.
With an active viral replication, the rate of CD4 cells
destruction might outweigh the rate of production of newer cells.
Expenditures totaled $13,885 for individuals at the earliest stage of disease but rose steadily across declining strata of CD4 cell
counts, reaching $36,532 for those with the most advanced disease.
One possible approach would be to genetically engineer a CD4 cell
that cannot be infected by HIV.
Doctors can track the progress of HIV infection by measuring the number of CD4 cells
in the blood.
WHO guidelines issued in 2009 recommended antiretroviral therapy for people with a CD4 cell
count below 350 cells/m[m.
Twenty-eight years after the recognition of AIDS, the SILCAAT and ESPRIT trials have made us question the value of CD4 cell
counts as a universally applicable biomarker.