In this group of men who started a strong antiretroviral combination with fewer than 200 CD4 cells
, this analysis determined that a CD4 count at or under 200 (versus over 350) when the viral load first fell below 50 copies raised the risk of AIDS or death almost 11 times (Figure).
In a less healthy sample, there's less room for CD4 cells
to decline, he notes.
The difference between the r rials is that ESPRIT signed up people with a CD4 counl above 299, while SILCAAT signed up people with 50 to 299 CD4 cells
This indication is based on analyses of plasma HIV-1 RNA levels and CD4 cell
counts in a controlled study of Viread of 24 weeks duration and in a controlled, dose-ranging study of Viread of 48 weeks duration.
People over 40 years old, those with a lower CD4 count when interrupting treatment, and those restarting the same antiretrovirals they stopped tended to regain CD4 cells
more slowly in the 3 months after resuming therapy.
Currently, physicians track the progress of HIV infection by measuring the decline of CD4 cells
Populations of HIV-infected CD4 cells
produced large amounts of HIV, whether they came from asymptomatic or late-stage AIDS patients, but adding CD8 cells from long-term survivors or uninfected people shut down HIV production.
36 log(10) copies/mL, a mean CD4 cell
count of 427 cells/mm(3) and had received a mean of 5.
36 log10 copies/mL and a mean CD4 cell
count (a measure of disease-fighting cells in the blood) of 427 cells/mm3.
The agency also suggested that physicians use zalcitabine only for AIDS patients whose counts of CD4 cells
, a key immune system component, have dropped below 300 per cubic millimeter of blood.
Researchers concluded that CD8 cells may play a protective role in these mice by suppressing the CD4 cells
, which attack pancreatic islet cells (SN:3/31/90, p.
in NK cells as well as in T cells, including CD4 cells