In addition, new therapeutic approaches could result from modulating or delaying the senescence of CD8 cells
in patients with HIV.
26) Another MACS study found that higher quotients of activated (CD38-positive) CD8 cells
predicted progression to AIDS better than CD4 count, but researchers collected these cell samples from January through June 1992, in the days of one- and two-drug therapy.
counts rose by an average of 181 cells/[mm.
That's the indirect measure--it's not the CD4 cell that's directly impacting viral load, it's the CD8 cell
Three research groups now challenge that dogma with evidence showing that under certain conditions, CD8 cells
can make the CD4 protein and consequently become infected by the AIDS virus.
The control group had predominately CD8 cell
infiltrate which was inactive against the tumor.
Roederer and Leonard Herzenberg speculate that HIV disrupts the balance between naive and memory CD8 cells
by infecting them in the thymus before they have fully matured.
and his colleagues at Yale University propose that "autoreactive" T-lymphocytes are the real protecting influence and that CD4 and CD8 cells
combine forces for a destructive effect.
Indeed, Imagawa adds, the research provides preliminary evidence that a subpopulation of white blood cells called CD8 cells
may play a heretofore unrecognized role in suppressing viral activity in some infected individuals.
We will focus on diseases where the immunopathology is mediated by CD4 cells rather than CD8 cells
, which are known to be dependent for their activation on the pathway being blocked by IDEC-114," added Dr.
Commenting on the studies, Professor Plotnikoff stated, "In the studies conducted to date, there have been noted increases in CD8 cells
, or Cytotoxic T-cells, that attack the HIV virus.
When the researchers grew the men's white blood cells in the laboratory and removed the suppressor cells, called CD8 cells
, they found biochemical signs of the virus's presence.