counts were not related to the status HTLV infection, regardless of the patient's clinical status.
(26) Another MACS study found that higher quotients of activated (CD38-positive) CD8 cells
predicted progression to AIDS better than CD4 count, but researchers collected these cell samples from January through June 1992, in the days of one- and two-drug therapy.
But in a small group of HIV-infected people known as long-term nonprogressors, those CD8 cells
seem to stave off the development of AIDS, even in the absence of anti-HIV drugs.
The proportion of CD4 cells normally exceeds that of CD8 cells
But in the US study, the CD8 cells
suppressed the virus without killing the healthy CD4T cells.
After the infusion, the CD8 cells
in the infected mice revived and the levels of virus in their bodies decreased by a factor of four after a month.
By looking at the numbers of CD4 and CD8 cells
, checking the ratio between them and measuring the cytokine production, one can tell if a patient has HIV in only a few seconds.
The results of our study also showed that patients in meningitis/milliary group had the lowest number of CD8 cells
which was significantly different from control group.
The patients who made it to 52 weeks had an increase in these cells, with a median number that increased from 300 activated CD8 cells
per 1 million lymphocytes to 2,000 activated cells.
The researchers also used a new test for HIV-specific immune function--counting the proportion of virus-specific CD8 cells
by using flow cytometry to measure which of the cells produce gamma interferon in response to killed virus.
It also indicates that after being infected with HIV and moving into the lymph nodes, CD4 cells are more likely to die than are another type of infected T cell called CD8 cells
. Cloyd says that this finding could explain why the number of CD8 cells
does not dramatically decline during HIV infection.
They found that the original portions of the virus degrade 400 times faster in response to CD8 cells
than they would have if those cells weren't a factor - what scientists call significant "selective pressure" on the virus.