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Use of eszopiclone with alcohol or other CNS depressants may have additive effects.
Use caution when considering the concurrent use of Xyrem with other CNS depressants.
Death has been reported in nontolerant, nondependent individuals, especially in the presence of CNS depressants.
It is possible that other CNS depressants or psychotropic medications may exert similar effects on nighttime arousals as Zolpidem did in this study.
Part III is divided into 13 chapters covering Alcohol, CNS Depressants, Opioids, Cocaine, Marijuana, Amphetamines/Sympathomimetic Amines, Hallucinogens, Anticonvulsant and Antiarrhythmic Drugs, Antidepressant Drugs, Neuroleptic Drugs, Carbon Monoxide/ Cyanide, Inhalants, and Metals.
Mixed with opioid painkillers such us OxyContin and Vicodin, or CNS depressants such as Valium and Xanax, alcohol can slow breathing, causing respiratory failure and death.
Other CNS depressants and alcohol may add to this effect.
Patients must not take this with alcohol, sedatives or other CNS depressants.
One noticeable omission is the absence of any mention of the relatively new "date rape" drugs, flunitrazepam and y-hydroxybutyrate, in the chapter on CNS depressants.
Do not drink alcohol, or take other CNS depressants such as cough and cold medicines, certain pain medicines, and medicines that help you sleep while you take Diclegis.