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Related to Carbonic anhydrase inhibitor: acetazolamide
See: deterrent
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Alzuet et al., "Metal complexes of 5-tertbutyloxycarbonylamido-1,3,4-thiadiazole-2-sulfonamide (B-[H.sub.2]ats), a carbonic anhydrase inhibitor. synthesis and characterization of the copper(II) complex.
Once baseline electrophysiological parameters were established, the percent change of Isc was calculated after the tissue was exposed to the following transport inhibitors: ouabain, [Na.sup.+]/[K.sup.+] ATPase inhibitor ([10.sup.-4] M, serosal); bumetanide, [Na.sup.+]/[K.sup.+]/[Cl.sup.-] cotransport inhibitor ([10.sup.-3] M, serosal); DIDS (4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid, [Cl.sup.-]/[[HCO.sup.-].sub.3] exchange inhibitor ([10.sup.-3] M, luminal); amiloride, sodium channel inhibitor, ([10.sup.-3] M, luminal and serosal); acetazolamide, carbonic anhydrase inhibitor ([10.sup.-5] M, luminal).
It can be concluded from these results, that the electron donating halo groups by substituted on the benzene ring of hydrazide activate the vanadium (V) complexes to behave as carbonic anhydrase inhibitor. The case of complex 2c having fluoro substitution at ortho position is contrasting, being not active.
Roblin, "Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors," Journal of the American Chemical Society, vol.
In the treatment of PCH, strategies include drugs such as, indomethacin, carbonic anhydrase inhibitors and procedures that may lower intracranial pressure.
Acetazolamide, a carbonic anhydrase inhibitor, has been used in the adjunctive treatment of open-angle glaucoma and epilepsy.[1,2] More recently it has been found useful in the prevention or treatment of acute high-altitude (mountain) sickness.[3] When used in appropriate doses (250-mg conventional tablets every 8 to 12 hours or 500-mg extended-release capsules every 12 or 24 hours) begun 24 to 48 hours before ascent and continued for at least 48 hours after arrival (or longer as needed), it has been found effective in relieving acute mountain sickness symptoms in 63.8% of patients.[4] Side effects, however, may limit the usefulness of acetazolamide for acute mountain sickness.[5]
(14) Other combination medications are available in a single bottle, such as Cosopt, which contains the beta-blocker timolol and a carbonic anhydrase inhibitor (dorzolamide).
Dorzolamide is a topical carbonic anhydrase inhibitor. It slows the production of bicarbonates and thus decreases sodium and fluid transport which in turn reduces the secretion of aqueous humor.
a) Topical prostaglandin analogue b) Topical beta-blocker c) Topical carbonic anhydrase inhibitor d) Laser trabeculoplasty
Carbonic anhydrase inhibitors act in the proximal convoluted tubule (Figure 3, B), and stop the excretion of hydrogen ions in exchange for sodium.
Carbonic anhydrase inhibitors: Schiff's bases of aromatic and heterocyclic sulfonamides and their metal complexes.

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