Therefore, inhibition of Th17 cell differentiation
has been identified as a potential therapeutic target in 1BD (Gizinski et al.
By elucidating the role of ERKs in B cell differentiation
, the current research provides valuable insight into a little-understood area of immune response, promising advances in drug discovery and offering hope to autoimmune disease and allergy sufferers around the world.
TransForm will screen complex mixtures in hopes of defining conditions that control cell differentiation
Epstein-Barr virus gene expression and epithelial cell differentiation
in oral hairy leukoplakia.
Whereas normal cells receive molecular information that stops cell proliferation and starts cell differentiation
, in the cancer cell the signals are either not present or not received.
The study shows how new biomaterials can take the guesswork out of identifying factors that drive stem cell differentiation
Extensive research has focused on soluble factors to optimize stem cell culture, but scientists are stymied when it comes to identifying the extracellular factors--such as hypoxia and atmospheric pressure--that are important drivers of stem cell differentiation
and cell function.
Objective: Defining the molecular mechanisms governing memory T cell differentiation
and homeostasis is of pivotal importance to generate durable and protective T cell responses against infections and cancers.
Scientists at RIKEN, led by senior author Hiroshi Ohno, MD, PhD, teamed up with Williams' laboratory, taking advantage of a discovery by Williams that a protein called RANKL, which is produced by cells in Peyer's patches, can induce M cell differentiation
of neoplastic cells originating in the oral and craniofacial regions.
The suspicion that these problems may be related to PCBs' effects on the timing and type of brain cell differentiation
led to the current study.
Gage's study "intersects two really important and emerging areas: noncoding RNAs and stem cell differentiation
," says Mandel.