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fibroblast growth factor-2 (FGF), platelet-derived growth factor (PDGF), epidermal growth factor (EGF) bind to specific cell-surface receptors and initiate an intracellular signal transduction cascade involving the sequential phosphorylation of Ras, Raf, Map kinase kinase (MEK), and ERK.
Now, in Nature, the SB scientists report that they have also identified the human cell-surface receptor, a protein designated human GPR14, to which U-II binds.
In healthy people, Prp acts as an ordinary cell-surface receptor, but its function is not clearly understood.
Both companies are testing hybrid molecules composed of the natural cell-surface receptor for TNF coupled to the back end of an antibody.
By preventing the cytokine from binding to its cell-surface receptor and signaling a reaction, soluble cytokine receptors may be capable of turning off inflammatory responses in a broad spectrum of autoimmune and inflammatory diseases.
Takao Shimizu at the University of Tokyo, with colleagues there and at the Protein Engineering Research Institute in Osaka, has cloned the cell-surface receptor for a blood compound called platelet-activating factor (PAF) -- one of the body's most potent alarm chemicals and the one responsible for much of the biochemical mayhem underlying asthma attacks and other inflammatory reactions.
In 1988, researchers isolated and inserted into cultured cells the gene for a cell-surface receptor called D2, which responds to dopamine by inhibiting certain chemical reactions inside cells.
TACI is a cell-surface receptor found on B lymphocytes, cells in the blood responsible for producing antibodies.
TACI is a cell-surface receptor found on B lymphocytes, the cells in the blood responsible for producing antibodies.
Receptors for advanced glycation end products (RAGE) are cell-surface receptors expressed by alveolar type I (ATI) epithelial cells and are implicated in mechanisms of alveolar development and sustained pulmonary inflammation.