Effects of MDL28170 on neurological defects, cerebral contusion
volume, and blood-brain barrier integrity
8 Table 2: Incidence of skull fracture and cerebral contusion
Site of fracture No.
It is generally well accepted among neuroradiologists that the HU (and therefore density) of cerebral contusions
decreases over time.
7%) were referred to a tertiary centre because of deterioration in general condition and coexisting pathologies, including spinal injury due to vertebral fracture (n=5), subdural haemorrhage and cerebral contusion
(n=4), hemorrhagic shock due to laceration of liver
A computed tomography (CT) scan upon admission revealed a depressed skull fracture with an underlying frontal cerebral contusion
and intraparenchymal bone fragments (Fig.
These authors referred to two other cases in the literature of hemorrhage into a lacerated frontal lobe occurring several weeks after "cerebral blast concussion" (shell explosion) with no solid blow to the head and to additional case reports of cerebral edema, petechial and meningeal hemorrhages, cerebral contusion
and laceration, and intracerebral and subdural hematoma after a cerebral blast injury.
While air-filled organs are especially susceptible, the brain is vulnerable to direct injury from cerebral contusion
or indirect injury--a cerebral infarction secondary to air emboli.