Chief cells were predominated among the cell population.
Photomicrograph showing
chief cells, which are nonimmunoreactive for CAM 5.2 (original magnification X20).
A few of the endocrine cells distributed in the gastric glands, with round, conical or triangular in shape, which were mainly embedded in the
chief cells. The cytoplasm of the endocrine cells were filled with tiny argyrophilic granules so that we could observe at the neck and body of glands with Gordon-Sweet's staining.
(2005) (12) quoted oxyphil cells as less numerous than the
chief cells. The present finding revealed the same.
Citation: "Differentiated Troy+
chief cells act as 'reserve' stem cells to generate all lineages of the stomach epithelium"; Stange DE et al.; Cell, October 2013
While most adenomas are composed of
chief cells, a small percentage may be oxyphilic (>90% oxyphils) and rare "water-clear" adenomas have also been described.
Histologically, the tumor was composed of uniform small round cells (
chief cells) arranged in discrete cohesive lobules (zellballen).
The thymic tissue appeared as a single lobule divided by fine, fibrous septa, and the parathyroid tissue was made up entirely of
chief cells. Both the periphery and the center of the nodule contained a dense population of lymphocytes and typical Hassall's corpuscles (figure, B).
Finally, mixtures of different cells (oxyphils, clear cells, and
chief cells) can be found in adenomas, as well as in hyperplastic glands.[3] The most important criterion is the clinical follow-up--no recurrence of hypercalcemia on long-term follow-up (at least 5 years) supports the diagnosis of adenoma.
The
chief cells are strongly and diffusely immunoreactive with chromogranin and synaptophysin, while the supporting sustentacular cells react with S-100 protein (figure 2).
Step serial sections of the right inferior parathyroid showed one cluster of WCCs, but otherwise the gland consisted almost entirely of
chief cells, with rare small clusters of transitional oxyphil and oxyphil cells.
Microscopically, the glands are nodular, and examination will identify an increase in parenchymal-cell mass, composed of
chief cells and/or oxyphilic cells (figure).