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In the study of cholic acid for the treatment of peroxisomal disorders in 31 children, improvements in baseline liver function tests and weight were noted in 46%; 42% of patients survived longer than 3 years.
These included a deoxycholic acid culture at 8 mg/ml and 3 cholic acid cultures with the following concentrations: 16 mg/ml, 8 mg/ml and 4 mg/ml.
The present experiment showed that sECC (200 mg/kg) significantly decreased the serum and hepatic total cholesterol, triglyceride, and the LDL cholesterol in hypercholesterolemic (high cholesterol plus cholic acid diet) mice compared to model mice.
The experimental diet consisted of a well pulverized mixture of cholesterol (1%), cholic acid (0.
The resulting cholic acid "is not a good fat emulsifier," notes Nicholson, a coauthor of the study--and after the probiotic treatment there was a 50-fold higher ratio of cholic to taurocholic acid in the treated animals' guts.
3-[(3-Cholamidopropyl)-dimethylammonio]-1-propanesulphonate (CHAPS) and 3-[(3-cholamidopropyl)-dimethylammonio]-2-hydroxy-1-propanesulphonate (CHAPSO) were from Calbiochem (Darmstadt, Germany); N-(2-hydroxyethyl)-piperazine-N'-(2-ethanesulphonic acid) (Hepes), tris(hydroxymethyl)aminomethane (Tris), ethylene glycol-bis([beta]-aminoethyl ether)-N,N,N',N'-tetraacetic acid (EGTA), 1,6-diphenyl-1,3,5-hexatriene (DPH), sodium dodecyl sulphate (SDS), phenylmethylsulphonyl fluoride (PMSF), aprotinin, benzamidine, digitonin, cholic acid, deoxycholic acid, n-dodecyl-[beta]-D-maltoside (DBM), and dodecylpoly[(ethylene-glycolether).
A third group ate a standard diet enhanced with a mixture of phytosterols, plus cholic acid.
The cytotoxicity of individual bile acids reflects levels of hydrophobicity; chenodeoxycholic and deoxycholic acids are more cytotoxic than cholic acid (3).
According to the blood-lipid lowering mechanism and chemical structure, Western hypolipidemic agents under clinical application and R&D can be divided into statins, niacins, fibrates, cholic acid chelating agents, polyenes, new-type hypolipidemic agents and various compound preparations.