An association study between the
Clara cell secretory
Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in
Clara cell secretory protein.
70,93) The existence of a putative bronchioloalveolar stem cell, likely corresponding to the variant
Clara cells, has been suggested by experimental studies to be located at the bronchioloalveolar duct junction.
We exposed murine
Clara cells, which are known to express functional Nat2, the murine ortholog of human NAT1 (Kawamura et al.
These findings suggest that
Clara cell injury by bioactivated chemicals in the developing animal is not necessarily predicted by the level of CYP450 enzyme activity.
Inhaled naphthalene causes dose dependent
Clara cell toxicity in mice but not in rats.
In the terminal bronchioles, ciliated and
Clara cells begin invading the alveolar airspace.
The researchers theorize that repeated exposure to disinfection by-products around indoor swimming pools may damage
Clara cells, decreasing production of CC16 and possibly masking any effect that ozone exerts on CC16 levels.
urea and sweat) in pools may decrease the CC16 secretion because of
Clara cell dysfunction or damage.
In the present study, we investigated the role of
Clara cells in inflammation and fibrosis in vivo by exposing
Clara cell-ablated mice to crystalline silica, which is known to cause pulmonary fibrosis (30-33), and examined the gene expression of MMP-2 and MMP-9 in lung tissue using reverse transcription-polymerase chain reaction (RT-PCR).
The
Clara cell protein, CC16: a biomarker of pulmonary toxicity.
The FGF caused the variant
Clara cells to revert to their original stem-cell state.
