Clara cell: Progenitor for the bronchiolar epithelium.
By comparison, CC16 is a secreted product of the respiratory epithelium produced primarily within the
Clara cells of the distal respiratory and terminal bronchioles of the lung.
Katyal, "
Clara cells and
clara cell 10 kD protein (CC10)," American Journal of Respiratory Cell and Molecular Biology, vol.
Clara cells and AECII cells were also recognized as lung stem cells.
An association study between the
Clara cell secretory
Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in
Clara cell secretory protein.
The identification of proteins typical of alveolar type II cells and
Clara cells (such as SP-A, SP-B, SP-C, and CC16) further supports the hypothesis that PEx is formed in the distal airways.
Regionally distinct resident cells with stem/progenitor characteristics include basal cells and their side population [9, 10],
Clara cells and their variants [11], bronchoalveolar stem cells [12], alveolar epithelial type II progenitor cells [13, 14], lung-derived mesenchymal stem cells (MSCs) [15], and [c-kit.sup.+] stem cells [16-19].
Clara cell protein as a marker of
Clara cell damage and bronchoalveolar blood barrier permeability.
To determine whether gestational SS broadly affected the airway secretory functions, we examined airway Clara and goblet cells in FA- and SS-exposed mouse lung sections at PD7 by staining for CCSP and SP-B (
Clara cell markers) and SPDEF (goblet cell marker).
Stripp, "
Clara cell secretory protein deficiency increases oxidant stress response in conducting airways," The American Journal of Physiology: Lung Cellular and Molecular Physiology, vol.
Both MGA and MGB and several related genes [e.g.,
Clara cell 10-kDa protein, lipophilin A, and lipophilin B (LPB)] are localized in a dense cluster on chromosome 11q12.2 (8).