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Related to Classical complement pathway: Alternative complement pathway
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The other face ofCRP, the A-face, is known to activate the C1q-dependent classical complement pathway by binding C1q (Fig.
C2 and C4, both early components of the classical complement pathway, are almost always low in RAE patients, with C4 being a common screening test for this condition owing to its widespread availability.
By blocking the alternative pathway, the majority of the negative consequences of inappropriate complement activation can be attenuated while leaving certain aspects of the classical complement pathway available for normal host immune defense.

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