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Related to Classical complement pathway: Alternative complement pathway
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The other face ofCRP, the A-face, is known to activate the C1q-dependent classical complement pathway by binding C1q (Fig.
C1-INH acts as the primary regulator of the classical complement pathway by inhibiting C1r and C1s, 2 early components of this pathway.
The large protamine-heparin complexes formed after protamine administration can activate the classical complement pathway, a type of inflammatory immune response (Morel et al.

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