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Prothrombin plays an integral part in the coagulation cascade as a precursor to thrombin, an essential element in clot stabilization.
TB-402 is a recombinant human monoclonal antibody that partially inhibits Factor VIII, a key component of the coagulation cascade.
The low activity of coagulation inhibitors in severe malaria is important, not only due to their regulatory role in the coagulation cascade but also because of their anti-inflammatory properties (14).
Factor XIII is the final enzyme in the coagulation cascade and is responsible for catalyzing the intermolecular cross-linking of fibrin polymers, therefore increasing the mechanical rigidity of the fibrin clot (1).
Fondaparinux is a synthetic inhibitor of factor Xa, an early step in the coagulation cascade, and uses a different mechanism than do unfractionated heparin and the low-molecular-weight heparins, which block other coagulation factors.
It is postulated that the severe local infection and inflammation activates the local coagulation cascade culminating in thrombosis and downstream embolism.
Factor VIIa plays an important role in the blood coagulation cascade and recombinant Factor VIIa is used to treat and prevent bleeding episodes in hemophilia A and B patients with inhibitors to Factor VIII or Factor IX, and in patients with acquired hemophilia.
Further support of the micro-array data that identified changes in gene expression by probing the messenger RNA (mRNA) levels was pursued by measuring specific proteins within the complement and coagulation cascade using plasma from SUSTAIN and ASSURE trials.
Factor VII (earlier called proconvertin) is amongst the proteins that leads to blood clots in the coagulation cascade.
Dabigatran etexilate is a novel oral direct thrombin inhibitor which specifically and reversibly inhibits thrombin, the central and essential enzyme in the coagulation cascade responsible for thrombus (clot) formation(v),(vi).
The extent of hemolysis and the presence of these factors activate platelets and, subsequently, the coagulation cascade.
Underlying conditions include problems with platelet function, the coagulation cascade, or poor dermal support typically resulting from chronic corticosteroid use or sun damage.