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That is, they prevent aggregation of red blood cells, which as you may recall, is part of the coagulation cascade.
It has been suggested that inhibition of more proximal stages of the coagulation cascade might be more effective in inhibiting atherothrombosis.
The coagulation cascade sustains a prothrombotic state when not actively being modulated by the anticoagulant pathways as a result of activation of TF pathways.
Second, triggers leading to thrombus formation may involve stimulation of monocytes in the blood that lead to activation of factor X, an important enzyme in the coagulation cascade.
The inhibition disrupts the intrinsic and extrinsic pathways of coagulation cascade, there by the formation of thrombus is prevented.
The coagulation cascade is possibly activated because the inflammatory cascade stimulates tissue factor (TF) expression, attenuates fibrinolysis by stimulating the release of plasminogen activator inhibitors (PAI), and finally causes fibrin deposition in the airspaces and lung microvasculature (Levi and Ten Cate 1999; Abraham 2000; Ware et al.
This reaction involves a primitive evolutionary coagulation cascade in which proteases are sequentially activated, thus resulting in the formation of a clot.
In addition to coagulation cascade activation, inflammatory response plays a role in thrombus formation via production of microparticles (MPs) that carry cell-specific molecules--proteins such as galectins (6).
Plasma hemostasis is a series of reactions known as the coagulation cascade, that is, a series of enzymatic reactions that ends in the formation of a fibrin protein fiber mesh (Vavilova et al.
Fibrin sealants imitate the coagulation cascade, generating a strong fibrin clot.
Blood clots form in the coagulation cascade and then fibrin--the mesh-like fibers that bind a blood clot together--is deposited in the clot.
The coagulation cascade is part of a series of events that leads to haemostasis after a vascular injury.