VBI-1901 is administered intradermally and is adjuvanted with granulocyte-macrophage colony-stimulating factor
(GM-CSF), a potent adjuvant that mobilizes dendritic cell function.
United Kingdom-based GSK has commenced a phase III clinical development programme with otilimab, an investigational anti-granulocyte macrophage colony-stimulating factor
monoclonal antibody, it was reported yesterday.
G-CSF (granulocyte-colony stimulating factor), also known as colony-stimulating factor
3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.
We evaluated the concentrations of a select panel of cytokines, including innate immune mediators (interferon [IFN]-[gamma], interleukin [IL]-15, IFN-P); inflammatory factors (IL-6, IL-18, soluble intercellular adhesion molecule 1 [sICAM-1]); chemokines (CC-motif chemokine ligand [CCL] 3, CCL-4, CXC-motif chemokine ligand [CXCL] 1, CXCL-8, CXCL-10); hematopoietic factors (granulocyte colony-stimulating factor
[G-CSF], granulocyte-macrophage colony-stimulating factor
); the angiogenic factor vascular endothelial growth factor A (VEGF-A); and proteases (matrix metalloproteinase [MMP]-2, MMP-9).
The protective effect of granulocyte colony-stimulating factor
on endometrium and ovary in a rat model of diabetes mellitus.
LOW-DOSE TREATMENT with plerixafor, a CXC chemokine receptor 4 antagonist, was well tolerated and markedly improved severe presentations of warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome in three patients who could not receive granulocyte colony-stimulating factor
Identification and characterization of receptors for granulocyte colony-stimulating factor
on human placenta and trophoblastic cells.
TJM2 is a humanised immunoglobulin G1 (IgG1) targeting granulocyte-macrophage colony-stimulating factor
(GM-CSF) and is the first candidate from I-Mab's innovative proprietary pipeline to be approved for clinical trials by the FDA.
Keywords: Neonatal sepsis, neutropenia, Granulocyte Colony-Stimulating Factor
Pegfilgrastim, a granulocyte colony-stimulating factor
(G-CSF) receptor agonist, is used to stimulate bone marrow to produce more neutrophils in order to decrease the incidence of infection in patients undergoing chemotherapy.
Objective: To determine the effectiveness of granulocyte colony-stimulating factor
(G-CSF) in the reduction of atherosclerotic lesions in a rabbit animal model.
Baby developed severe neutropenia at DOL 2, with absolute polymorphonuclear count <500 [micro]/L, and was started with granulocyte colony-stimulating factor
. Due to favorable clinical evolution in addition to negative blood culture, Ampicillin-Gentamicin were discontinued at DOL 5.