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Pharmacologic effects of PDE-III/PDE-V inhibition include vasodilation, smooth muscle relaxation, and platelet aggregation inhibition, due to decreased degradation of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP).
These negative effects may result from the effect of antidepressants on cyclic adenosine monophosphate (cAMP), they said.
Summers went on to say, "In scientific terms, we have known for some time that PGE-1 increases cyclic adenosine monophosphate (cAMP) by regulating the calcium in cells.