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Abbreviations: ALL, acute lymphoblastic leukemia; ATF4, activating transcription factor-4; ATF6, activating transcription factor-6; CHOP, C/EBP homologous protein; CPT, cryptotanshinone; DDIT3, DNA damage-inducible transcript 3; elF, eukaryotic initiation factor; ER, endoplasmic reticulum; ERAD, ER-associated degradation pathway; IPA, Ingenuity Pathway Analysis; IRE1, inositol-requiring enzyme-1; mTOR, mammalian target of rapamycin; PERK, protein kinase RNA-like endoplasmic reticulum kinase; PI3K, phosphoinositide-3-kinase; ROS, reactive oxygen species; UPR, unfolded protein responses; XBPI, X-box protein 1.
11) The second most commonly used FISH test was for DDIT3 gene region (12q13), which is split apart in t(12;16) and t(12;22) seen in myxoid liposarcoma.
Regarding the latter example, probes for DDIT3 can detect both the t(12;16) and the t(12;22) translocations in myxoid/round cell liposarcoma.