High frequency of mitochondrial DNA mutations
in glioblastoma multiforme identified by direct sequence comparison to blood samples.
This suggests that repeating patterns of DNA mutations
could be used as an indicator of treatment prognosis, helping to shape future therapies.
As the cells divide rapidly, they acquire new DNA mutations
, so a vicious circle of accelerated mutation ensues.
When subjected to higher UV exposure, DNA mutations
in the placebo group increased by 760%.
LHON is caused by mitochondrial DNA mutations
in subunits of NADH dehydrogenase (complex I), leading to reduced oxidative phosphorylation and energy production in retinal cells.
This is the first study investigating the impact of non-coding DNA mutations
in gastric cancer and we anticipate that it will inspire new research to further uncover the mechanisms and impact of these specific mutations."
Cancer is actually many thousands of different diseases, each with different underlying DNA mutations
. That's why drugs that are effective against one person's ovarian cancer may fail utterly against another's.
What differentiates the blood test from previous attempts is that it examines both DNA mutations
and proteins associated with cancer.
He said: "A novelty of our classification method is that it combines the probability of observing various DNA mutations
together with the levels of several proteins in order to make the final call."
"Others wondered how stress could possibly be related to a biological process that involves DNA mutations
and the growth of cancer cells within a particular organ, such as the pancreas."
However, in the samples from patients with colorectal, breast, lung, or ovarian cancer, the technique identified tumor-related DNA mutations
in 48 of 62 patients (77 percent) with advanced cancer (stages III and IV), and in 86 of 138 patients (62 percent) with stage I or stage II cancer.
They detected no cancer-related DNA mutations
in the samples from the healthy participants.