Successful treatment of linear Darier's disease
with topical adapalene.
In a local study of new patients with Darier's disease
seen at the National Skin Centre from 1982 to 2002, 3 of 24 unrelated patients had associated neuropsychiatric disorders.
Up-regulation of transient receptor potential canonical 1 (TRPC1) following Sarco(endo)plasmic Reticulum Ca ATPase 2 gene silencing promotes cell survival: a potential role for TRPC1 in Darier's disease
," Molecular Biology of the Cell, vol.
In Darier's disease
and ichthyosiform disorders a starting dose of 10 mg is more appropriate.
Punch biopsy from the lower back and excision biopsy from external genitalia were showed hyperkeratosis, suprabasal lacunae, corps-ronds and grains and hyperkeratotic invagination filled with keratinous material and acantholytic cells suggestive of Darier's disease
With Darier's disease
, skin lesions are often present in the second decade of life but rarely appear in adulthood.
5,6,7) However changes of erythronychia along with distil notching of the nail plate like that of Darier's disease
can be present in subungual glomus tumor as seen in our patient.
We selected 30 patients of Darier's disease
from the dermatology OPD for the study.
Multiple, dirty, warty papules coalescing into patches symmetrically distributed over neck, trunk and flexors of the extremities mimicking Darier's disease
The incidence and distribution of oral lesions in patients with Darier's disease
Common differential diagnoses of FLP include keratosis pilaris, Darier's disease
, follicular mucinosis and lichen scrofulosorum.
It can occur as isolated autosomal dominant trait, with mutations in ATPA2, the gene implicated in Darier's disease
is found to be involved.