Current efforts are focused on better harnessing the power of
dendritic cells, thereby enhancing the body's ability to combat disease.
Exposure to thimerosal at concentrations above 200 ppb caused immature
dendritic cells to die.
One study suggests that there are just as many activated
dendritic cells in psoriasis lesions as activated T cells, "perhaps even more," he said (Proc.
Proliferative lesions of follicular
dendritic cells: an overview, including a detailed account of follicular
dendritic cell sarcoma, a neoplasm with many faces and uncommon etiologic associations.
This additional intellectual property from The Rockefeller University expands NeoStem's comprehensive Targeted Cancer Immunotherapy Programme patent portfolio, which includes inventions relating to critical aspects of a
dendritic cell-based therapy, novel antigen-presenting cancer vaccines, stem cell growth media and methods to produce the high purity cancer initiating (stem) cells that provide the critical antigen array with which the vaccine's
dendritic cells are pulsed.
Some of these lymph nodes, exhibited prominent proliferation of cells showing morphologic features of follicular
dendritic cells with bland-looking ovoid nuclei, indistinct cell borders and small distinct nuclei.
Dendritic cells, like scouts in the field of a military operation, deliver key information about an invading pathogen that helps activate the T-cells in launching a more effective attack.
Unfortunately, tumors recruit and harbor T-regs to placate would-be attackers, so a major goal of cancer-vaccine research has been to stimulate
dendritic cells and weaken T-regs.
The neoplastic process associated with follicular
dendritic cells was first described by Monda et al in 1986.
Aastrom is currently engaged in on-going clinical trial collaborations at Stanford University evaluating
dendritic cells produced with this technology.
Population Council immunologist Melissa Pope has studied
dendritic cells and HIV for more than a decade.
T cells from community donors in conjunction with
dendritic cells derived in vitro.
