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Pathology consultation on monitoring direct thrombin inhibitors and overcoming their effects in bleeding patients.
Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate.
3) Direct thrombin inhibitors (Parenteral): These drugs are especially useful in cases of heparin induced thrombocytopenia (HIT).
Clinical monitoring of hirudin and direct thrombin inhibitors.
Parenteral direct thrombin inhibitors (DTIs) have been used in the pediatric population in a variety of patient care scenarios.
Two new classes of drugs, oral direct thrombin inhibitors (DTI) [2] and oral direct factor Xa inhibitors (DFXaI), are steadily obtaining regulatory approval for prevention of thromboembolic events in patients who have atrial fibrillation, undergo hip or knee replacement surgery, or require treatment of pulmonary emboli and deep vein thromboses.
A Patients with heparin-induced thrombocytopenia (HIT) are often anticoagulated with direct thrombin inhibitors (DTIs) until long-term anticoagulation with warfarin is achieved.
2,5,10,17) A direct thrombin inhibitor (DTI) must be administered for a minimum of 7 days.
Effects of melagatran, a novel direct thrombin inhibitor, in healthy volunteers, following intravenous, subcutaneous and oral administration.
As a direct thrombin inhibitor, reversal of the effects cannot be achieved with conventional therapy such as vitamin K or blood products.
4) A successful alternative to heparin is the direct thrombin inhibitor (DTI) class, including argatroban, lepirudin, and bivalirudin.