The patient began isoniazid, ethambutol, and rifampin under directly observed therapy
; he died 4 months later.
Daley, "Tuberculosis treatment outcomes: Directly observed therapy
compared with selfadministered therapy," American Journal of Respiratory and Critical Care Medicine, vol.
Finalmente en 1950, Karel Styblo desarrollo la estrategia DOTS (por sus siglas en ingles, directly observed therapy
short course) o tratamiento acortado directamente supervisado, la cual fue adoptada en 1995 por la OMS como estrategia mundial contra la TB; hoy dia es implementada como una estrategia obligatoria.
[5.] Seaworth BJ, Armitige LY, Griffith DE (2013) First do no harm-adverse events, drug intolerance, and hepatotoxicity: how can we not justify directly observed therapy
for treating tuberculosis?
Since 2012, New Mexico has been utilizing a "new" 12 week treatment regimen of Isoniazid (INH) and Rifapentine given by directly observed therapy
as the primary treatment for TB infection.
Key words: Tuberculosis (TB), pulmonary tuberculosis (PTB), adverse drug reactions (ADRs), directly observed therapy
short course (DOTS).
Directly observed therapy
(DOT) is preferred for certain high-risk patients with latent tuberculosis infection (LTBI), including those who are younger than 5 years of age, test positive for human immunodeficiency virus, are receiving immunosuppressive therapy, have chest radiography evidence of healed TB, have recently converted to active TB status while receiving serial TB testing, or have recently been exposed to active TB.
Directly Observed Therapy
Short-Course (DOTS), estrategia eficiente na busca da cura e erradigao da tuberculose
To prevent the spread of tuberculosis (TB) and limit the development of drug-resistant strains, the World Health Organization and the Canadian TB Standards recommend Directly Observed Therapy
(DOT) for TB patients.
Rumailah Hospital - Daily DOTs (directly observed therapy
) for the Communicable Diseases (CDC) clinic medication room will be open from 7am-9pm daily.
We do have a really good rate of finishing treatment in our DOTS (directly observed therapy
short course) program, 92%.
Participants were randomized to either the standard treatment regimen of daily self-administered isoniazid for 9 months, or a novel regimen consisting of directly observed therapy
with isoniazid (INH) and rifapentine (INN) once-weekly for 3 months.