bridge

(redirected from Disulfide bridge)
Also found in: Dictionary, Thesaurus, Medical, Financial, Encyclopedia.
Related to Disulfide bridge: Sulfur bridges
See: chain, connect, connection, contact, join, nexus, relate

BRIDGE. A building constructed over a river, creek, or other stream, or ditch or other place, in order to facilitate the passage over the same. 3 Harr. 108.
     2. Bridges are of several kinds, public and private. Public bridges may be divided into, 1st. Those which belong to the public; as state, county, or township bridges, over which all the people have a right to pass, with or without paying toll these are built by public authority at the public expense, either of the state itself, or a district or part of the state.
     3. - 2d. Those which have been built by companies, or at the expense of private individuals, and over Which all the people have a right to pass, on the payment of a toll fixed by law. 3d. Those which have been built by private individuals and which have been dedicated to public uses. 2 East, R. 356; 5 Burr. R. 2594; 2 Bl. R. 685 1 Camp. R. 262, n.; 2 M. & S. 262.
     4. A private bridge is one erected for the use of one or more private persons; such a bridge will not be considered a public bridge, although it may be occasionally used by the public. 12 East, R. 203-4. Vide 7 Pick. R. 844; 11 Pet. R. 539; 7 N. H. Rcp. 59; 1 Pick. R. 432; 4 John. Ch. R. 150.

References in periodicals archive ?
A study found that the disulfide bridge located in the N-terminal part (1-19) has a minor effect on membrane insertion properties and peptide conformational behaviour, suggesting that this disulfide bridge does not play a significant role in hIAPP/membrane interactions [75].
Disulfide bridges can also contribute to a protein's globular shape.
Novel synthetic analogues of avian [beta]-defensin-12: the role of charge, hydrophobicity, and disulfide bridges in biological functions.
These cysteine residues fold the mature peptide through disulfide bridges in all decapod families (Ventura et al., 2014).
She said, 'It helps in stiffening of outer dense fibers by formation of disulfide bridges or strong bonding protein molecules during sperm maturation, which is an essential step for generation of sperm motility, especially progressive motility as shown in the study.' Zinc deficiency affects sperm production, maturation and motility, as well as fertilizing capacity of the active matured sperm cells, the study said.
The extent of crosslinking was expected to be a primary parameter governing stability of the base polymer layer; moreover, by deactivating PMPMS thiols it serves to prevent their subsequent participation in immobilization of thiolcarrying biomolecules through alternate pathways such as formation of disulfide bridges [37].
Under reducing conditions, disulfide bridges in proteins are disrupted, whereas such interactions are preserved under nonreducing conditions.
In the article "Efficient Self-Assembly of mPEG End-Capped Porous Silica as a Redox-Sensitive Nanocarrier for Controlled Doxorubicin Delivery," porous nanosilica particles are modified with PEG shell via disulfide bridges and supramolecular interaction for drug delivery, with benefits of enhanced drug loading capacity and decreased risk of systemic toxicity.
For example, the formation of disulfide bridges within the peptide will create 'protein folding' containing the carbon-14 label.
(2015) Extracellular disulfide bridges stabilize TRPC5 dimerization, trafficking, and activity.
The mutagenesis data allowed for concluding that the presence of disulfide bridges is not required for folding of the Na,K-ATPase [alpha]-subunit and its subsequent activity [24].