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No deletion or duplication was detected in MLH1, MSH2, MSH6 genes, and EPCAM gene.
(7.) Tomita N, Yamano T, Matsubara N, Tamura K: [A novel genetic disorder of Lynch syndrome - EPCAM gene deletion].
In cancerous cells, a higher expression of EpCAM protein was observed (59.3% of cancers with a positive expression of EpCAM protein) in comparison with normal gastric mucosa (Figure 1).
EVs were identified by EpCAM-APC, and we assumed that all EpCAM binding ([mAb.sup.+]) particles were true EVs.
Patients with Lynch-like syndrome and Lynch syndrome caused by EPCAM deletion share common clinical features that differ from patients with Lynch syndrome caused by MMR, including a preference for the right colon, a lower degree of fulfillment of the revised Bethesda guidelines, and an older mean age at CRC diagnosis .
It works by detecting the EpCAM antigen, a transmembrane epithelial glycoprotein cell adhesion molecule found in humans.
In addition, most studies on the expression of EpCAM and AFP in HCC were performed in Asian populations.
Furthermore, an enhancer region (ID GH02H047342, localization chr2:47,342,469-47,347,454) described in the GeneCard Human Gene Database (http://www.genecards.org) that regulates both the BCYRN1 and the EPCAM genes is located near the rs13388259 SNP.
Exonal and intronal mutations in the EPCAM gene have been identified as the responsible defects in patients with IED [7-9].
Immunohistochemical panel is also important, with positivity of prostate-specific antigen, prostate acid phosphatase, EpCam, NKX3.1, and prostein .
Extensive immunostaining was performed, including hepatocellular carcinoma markers (AFP, HepPar1, Glypican-3, polyclonal CEA, and ARG1), other epithelial antigens (CK7, CK20, AE1/AE3, CAM5.2, EpCAM, and EMA) (Figure 1(d)), Inhibin, CD117, CD30, and CD3, and ALK-monoclonal, germ cell markers (AFP, OCT3/4, and HCG), melanoma markers (Melan-A, S-100, and SOX10), and endothelial (CD31) and muscle (smooth muscle actin) markers (Figure 1(e)) were all negative.
Additionally, EpCAM (epithelial cell adhesion molecule) in mice and its human homolog, tumor-associated calcium signal transducer 2, also participate in this cell adhesion .
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