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Sequence analysis of coltivirus genomes has shown that segment 6 of viral protein 6 (VP6) of CTFV is homologous to segment 7 (VP7) of EYAV (Figure 3).
CTFV from North America and EYAV from Europe show little cross-reactivity in neutralization assays.
The genome of CTFV contains 29,174 nucleotides, and that of EYAV contains 29,210 nucleotides (18).