perforation

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It is estimated that there are some 500,000 cases a year of eardrum perforations of which 150,000 require surgery.
The treatment of chronic eardrum perforations is an attractive niche market opportunity that will generate substantial returns at pharmaceutical margins.
The Cochrane Database published a systematic review of 9 randomized controlled trials in which systemic antibiotics were compared with topical antibiotics or antiseptics for the treatment of chronically discharging ears with underlying eardrum perforations in more than 800 patients of all ages.