T cells are critical immune effector cells
, and alteration in their function can have grave consequences on responses to primary infection and the acquisition of immunity.
In the present study, we addressed the immunotoxic potential of the herbicide PRN on the effector cells
of cell-mediated immunity, CTLs.
The assay is ADCC mechanism of action (MOA)-based and features frozen, thaw-and-use effector cells
, and optimized reagents and protocol to perform a reporter-based ADCC bioassay in a single day.
In one particular configuration, DART proteins can be used to redirect the body's cell-destroying, immune effector cells
against tumor cells.
The study strongly supports the belief that rather than being an uncontrolled inflammatory response, sepsis is the result of extensive apoptosis-induced depletion of immune effector cells
Importantly entinostat maintained the activity of the T effector cell
recruitment with novel Fv-based dual-affinity re-targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion.
It is thought that the T regulatory cells may protect against T effector cell
damage well after the drug has been eliminated from the body.
Our study is the first to demonstrate that Avastin, an anti-angiogenic agent, co-administered with Imprime PGG, an agent that enhances innate immune effector cell
function, results in synergistic anti-tumor effects," said Carolina Salvador, M.
When used as a boost after priming the immune system with best-in-class pDNA vaccines, VesiculoVax(TM)-vectored vaccines lead to the expansion of primed T cells into effector cells
that are uniquely suited to killing virally infected cells and cancers.
Objective: "Eosinophils, both as end-stage effector cells
and as Th2-immunomodulators, have the capacity to secrete varied inflammatory mediators, such as, cytokines and enzymes that are stored in their cytoplasmic secretory granules.
These Neukoplast cells can be re-engineered in a virus-free process to express surface receptors using Sorrento's G-MAB library to yield a stable line of effector cells
that recognize and target specific antigens on tumor cells.