Jothianandan, "Depression of contractile responses in rat aorta by spontaneously released endothelium-derived relaxing factor
," Journal of Pharmacology and Experimental Therapeutics, vol.
The randomised, double-blind, crossover study analysed by brachial artery flow-mediated dilatation (FMD), a measure of endothelial dysfunction since a low value is indicative of a blood vessel's inability to relax, and nitrate-mediated dilation (NMD), which relates to nitric oxide, a potent endothelium-derived relaxing factor
Also known as 'endothelium-derived relaxing factor
,' nitric oxide functions as a signaling molecule in a complex chain of events.
Nitrate is the measurable end point in serum used to assess levels of endothelium-derived relaxing factor
(EDRF), which in turn relates to nitric oxide levels.
By then, it was well established that NO is an endothelium-derived relaxing factor
The basis for the proposal that the acid-activatible inhibitory factor from bovine retractor penis is inorganic nitrite and the endothelium-derived relaxing factor
is nitric oxide.
The researchers speculate that people with healthy blood vessels react to epinephrine's vessel-constricting message by stepping up production of a natural, nitroglycerine-like substance called endothelium-derived relaxing factor
Indirect evidence for release of endothelium-derived relaxing factor
in human forearm circulation in vivo: blunted response to essential hypertension.
Shortly afterward it became clear that nitric oxide had important functions in the regulation of vascular tone, and it was demonstrated that nitric oxide was identical to endothelium-derived relaxing factor
, a factor derived from endothelial cells that induced relaxation of smooth muscle cells.