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Enterochromaffin cells release melatonin into nearby blood vessels of the mucous membrane of the inner lining of the stomach and intestines.
It is thought that CT stimulates enterochromaffin cells to release serotonin, and that serotonin then promotes the release of the secretagogue vasointestinal peptide from intestinal neural networks (40).
LX1031 acts locally on enterochromaffin cells in the GI tract to inhibit tryptophan hydroxylase, the rate-limiting enzyme in the synthesis of serotonin," explained Dr.
Serotonin (5'-hydroxy tryptamine; 5-HT) is a bioamine, which is synthesized from L-tryptophan mainly in enterochromaffin cells of the gastrointestinal tract and central nervous system.