These factors include temperature, pH, carbon : nitrate ratio, substrate diffusion, and denitrification
enzyme induction status.
Protein binding and liver
enzyme induction properties of AEDS can influence the blood levels of other drugs as well as other AEDS.
Monocytes also demonstrate higher induction ratios than lymphocytes [13] which require mitogen activation prior to
enzyme induction [14, 15].
Although the time needed to produce maximal
enzyme induction with nafcillin is unknown, its half-life is 0.
1997), which is also based on
enzyme induction, was significantly associated with TSH levels ([beta]= 0.
This confirmed that Danshen has no
enzyme induction effect on rat CYP1A2, despite previous findings that Danshen extracts may exert an inducing effect of CYP1A2 in the mouse (Kuo et al.
Patients who may be susceptible to effects from loss of
enzyme induction (including smokers receiving olanzapine or clozapine or others taking 3A4/PGP inducers) must be identified, and plans made for dosage adjustments if inducing agents are discontinued for a sufficient time ([greater than or equal to]1 week) to result in downregulation of CYP or PGP activity.
Results for hepatic
enzyme induction biomarkers are presented in Table 2.
Role of phase 2
enzyme induction in chemoprotection by dithiolethiones.
By using in vitro assays of CYP
enzyme induction or inhibition the properties of a large number of isolated pure compounds can be conveniently estimated.
MultiCell's progenitor cells and immortalized liver cells are used by XenoTech, Pfizer, Bristol Myers Squibb and a growing number of other pharmaceutical companies to improve the safety profile of drugs by identifying early in the drug development program those drug candidates that can cause clinically significant
enzyme induction and drug-drug interactions.
Physiologically based pharmacokinetic models have demonstrated that 10-fold differences in enzyme levels may make little difference in bioactivation of a chemical, as the chemical is completely metabolized at low doses in the absence of
enzyme induction.
