This occurs at a more rapid rate when there has been enzyme induction
due to, for example, chronic alcohol use.
Specific and dose-dependent enzyme induction
by omeprazole in human beings.
An ideal AED would have high oral availability, no or low protein binding, a long half-life, linear kinetics (increases in dose yield proportionate increases in serum level), no active metabolites, no liver enzyme induction
and no or few side effects.
15 Tools and Strategies for the Assessment of Enzyme Induction
in Drug Discovery and Development
and dietary chemicals as approaches to cancer chemoprevention: the Seventh DeWitt S.
References supporting microsomal enzyme induction
by individual PCB congeners in animals.
As microsomal enzyme induction
associated with hepatocellular hypertrophy can pose a potential risk in drug interactions, the presence and degree of hepatocellular hypertrophy is an important consideration in drug development.
While a gradual titration schedule is advisable, a relatively high dose may ultimately be required, reflecting liver enzyme induction
that can follow years of drinking, Dr.
is the process by which exposure to certain substrates (e.
The final part introduces the mechanisms leading to increases or decreases in enzyme activities as the concept of enzyme induction
via nuclear receptors and the different mechanisms of enzyme inhibition are explained.
3 days) was used as positive control for enzyme induction
Physiological modeling of a proposed mechanism of enzyme induction