These factors include temperature, pH, carbon : nitrate ratio, substrate diffusion, and denitrification enzyme induction
Protein binding and liver enzyme induction
properties of AEDS can influence the blood levels of other drugs as well as other AEDS.
This study was designed to examine the association between smoking habits and monocyte AHH activity, and to investigate any possible age-associated difference in enzyme induction
Sufficient evidence now indicates that nafcillin may cause clinically relevant hepatic enzyme induction
.[1-5] To date, however, only one report has addressed the potential eraction of dicloxaciltin and warfarin. The case reported herein further demonstrates the interaction of these orally administered agents.
References supporting microsomal enzyme induction
by individual PCB congeners in animals.
While a gradual titration schedule is advisable, a relatively high dose may ultimately be required, reflecting liver enzyme induction
that can follow years of drinking, Dr.
Phenobarbitone (40 mg/kg/day, i.p., 3 days) was used as positive control for enzyme induction
. One day after the final pre-treatment, the rats were anaesthetized and pharmacokinetics experiments were performed as described in the previous section.
However, few studies have evaluated the effects of enzyme induction
on antipsychotic drug levels, (9), (10) and the literature rarely discusses changes in serum drug levels after loss of enzyme or drug transport induction.
Most of the exposures were well above the median efffective dose (E[D.sub.50]) for enzyme induction
(Santostefano et al.
For ACE, enzyme induction
appears to be associated with mitogen-activated protein kinase and early growth response 1 transcription factor (Day et al., 2001).
Physiological modeling of a proposed mechanism of enzyme induction
We measured biomarkers indicative of liver enzyme induction
and investigated the relationship with organochlorine body burden in adult volunteers from this population.