The immunohistochemistry of epithelioid hemangioma with a vascular marker will show that these
epithelioid cells are vascular in origin.
Sheets of atypical
epithelioid cells with prominent eosinophilic cytoplasm and occasional intracytoplasmic lumina (hematoxylin-eosin, original magnification X200).
Large
epithelioid cells [11] and pleomorphism are occasionally described [12] and there is usually prominent mitotic activity and focal necrosis.
Immunohistochemically, the
epithelioid cells were positive for CD68, while the spindle cells were diffusely positive for CD34 and focally positive for smooth muscle actin (SMA) (Figures 3(a) and 3(b)).
In this study tuberculous infection was the most common opportunistic infection, which was grouped into caseous necrosis with
epithelioid cell granulomas in Table 4.
Presence of sheets of
epithelioid cells with lymphocytes and plasma cells with or without multinucleated giant cells were diagnosed as granulomatous lymphadenitis, and eosinophilic granular material containing inflammatory cells and necrotic cell debris was defined as caseous necrosis.[7] The TB abscess was described as degenerate caseous necrosis and/or liquefied necrotic material with marked degenerating and viable inflammatory cell infiltration without epithelioid granuloma.[8]
Epithelioid AML, the second group of renal AMLs, are composed of sheets of
epithelioid cells that can behave aggressively, with the potential for metastasis and resultant adjuvant therapy.[sup.11] Moreover, some retrospective pathologic studies have illustrated that previously diagnosed RCC were actually epithelioid AML.[sup.12]
The typical histopathologic feature is the presence of granulomas with central caseous necrosis; the areas of necrosis are surrounded by
epithelioid cells and by Langhans' giant cells that feature multiple nuclei arranged in a horseshoe-shaped pattern.
Within myxoid lobules, the neoplastic spindle and
epithelioid cells often interconnect with one another to form strands, complex networks (Figure 12), and discohesive sheets (Figure 13) forming a so-called dilapidated brick wall pattern.
Epithelioid cells home some role in limiting the infections.
Group-3: mainly necrotic material with many polymorph without
epithelioid cells, or giant cells.
Histopathology of skin biopsy revealed dense tuberculoid granulomatous infiltrate made up of lymphocytes, plasma cells, histiocytes and
epithelioid cells with occasional Langerhan's giant cells.
