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"Without adequate and timely repolarization, the excitation-contraction coupling sequence will become dysfunctional, leading to abnormal contraction."
The increased NCX has been found to be involved in the regulation of several parameters of cardiac excitation-contraction coupling, such as cytosolic Ca [sup]2+ concentration, repolarization, and contractility.[sup][5],[6],[8],[10],[15] Therefore, increased NCX activity has been identified as a mechanism promoting HF, cardiac ischemia, and arrhythmia.
Eccentric exercise- induced morphological changes in the membrane systems involved in excitation-contraction coupling in rat skeletal muscle.
In the absence of blood lactate an impairment of the excitation-contraction coupling has been suggested to be responsible for the changes in MDF [44] and the selective injury of the fast twitch fibers after eccentric exercise [45].
Allen, "Functional defects in six ryanodine receptor isoform-1 (RYR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling," Journal of Biological Chemistry, vol.
Dulhunty, "Skeletal muscle excitation-contraction coupling: who are the dancing partners?" International Journal of Biochemistry and Cell Biology, vol.
However, eccentric contractions induce impairment in excitation-contraction coupling as well (Allen, 2001; Warren et al., 1993).
In cardiac muscle, excitation-contraction coupling (ECC) is mediated by [Ca.sup.2+] influx through voltage-gated [Ca.sup.2+] channels (dihydropyridine receptors, DHPRs).
Thus, the performance of unaccustomed exercise results in mechanical disruption to the cellular structure of muscle (43) that changes the excitation-contraction coupling system (33).
Caffeine's ergogenic effect could be explained by (i) a reduction of the sensation of fatigue induced by exercise [2], (ii) an enhancement of the excitation-contraction coupling [3] and (iii) a stimulation of the central nervous system [4].