Keywords: Factor V Leiden mutation
, Recurrent pregnancy loss, PCR (Polymerase chain reaction).
Aortic arch thrombosis in a neonate with heterozygous carrier status of Factor V Leiden Mutation
Individuals with Factor V Leiden mutation
therefore have decreased deactivation of both FVa and FVIIIa and increased risk of thrombosis.
Guedon C, Le Cam-Duchez V, Lalaude O, Menard JF, Lerebours E, Borg JY: Prothrombotic inherited abnormalities other than factor V Leiden mutation
do not play a role in venous thrombosis in inflammatory bowel disease.
The presence of the factor V Leiden mutation
increases the risk of VTE and pregnancyrelated morbidity to 1/500.
Gurgey A, Balta G, Boyvat A: Factor V leiden mutation
and PAI-1 gene 4G/5G genotype in thrombotic patients with Behcet's disease.
Factor V Leiden mutation
is present in the 4-6% of the general population and is the most common inherited cause of the syndrome accounting for the 40-50% of cases (1).
Detection of the factor V Leiden mutation
by a modified photocross-linking oligonucleotide hybridization assay.
They concluded that their study showed a significant increase in the prevalence of the factor V Leiden mutation
, leading them to the conclusion that patients with factor V Leiden mutation
have a predisposition for MI.
A woman between the ages of 28 and 45 with [genetic thrombophilia], such as the factor V Leiden mutation
, and who also uses oral contraceptives has an increased risk of thrombosis, but she may ultimately manage to avoid having a thrombotic episode.
Eighteen patients consented to a prospective hypercoagulability evaluation that included assays for protein C, protein S, APC resistance, factor V Leiden mutation
, anticardiolipin antibodies, antineutrophil cytoplasmic antibodies (ANCA), rheumatoid factor, antithrombin III, anti-smooth muscle antibody, and lupus anticoagulant panel.
American College of Medical Genetics consensus statement on factor V Leiden mutation