(redirected from Fc receptor)
Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to Fc receptor: Complement receptor, ADCC
See: receiver
Mentioned in ?
References in periodicals archive ?
Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene.
Thus, in order to explore what particular Fc receptor could induce NET formation, PMN were stimulated by cross-linking individual receptors with specific monoclonal antibodies.
2008 180:6382) or transduce human Fc receptor and a luciferase reporter gene that allows modeling of the NFAT response elements of the IL-2 promoter to model PBMC derived ADCC (based upon the potency of antibody Fc effector function in ADCC pathway activation in effector cells, mAbs 2012 4:p310).
Unlike IgG, IgY antibodies do not bind to bacterial Fc receptors, such as staphylococcal protein A or streptococcal protein G (JENSENIUS et al.
NHance achieves this through 2 specific mutations in the antibody Fc region (at His433 and Asn434), resulting in an improved affinity of antibody binding to the neonatal Fc receptor at acidic pH.
These distinct groups of genes, along with Fc receptor genes, were the major genes altered by TCDD and DEX in the DC maturation pathway.
Furthermore, it is possible that polymorphic or somatic tumour-associated structural or functional defects of Fc receptor might account for reduction in trastuzumab-mediated ADCC response [28,29].
In addition, well-known recent clinical results indicate that the species specificity of Fc receptor binding must be given greater consideration during development of future antibody drugs.
MDX-1401 is enhanced for greater Fc receptor mediated antibody activity, one critical mechanism in tumor lysis by antibodies, using BioWa's Potelligent Technology.
Arthron has recently demonstrated that activation of its proprietary target, the Fc receptor on white blood cells is a major source of release of high levels of TNFa.