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Variable and fixed large airway obstruction often gives rise to strikingly abnormal flow-volume loops.
The flow-volume loop measuring both FEV1 and FEF25-75 has been shown to be a reliable and simple test to document the very beginning of lung rejection in lung transplant patients.
Comparing with the initial test, a repeated flow-volume loop showed normalization of the curve.
Typically, during the first portions of the flow-volume loop, the flows from the heliox loop are higher than the flows from the room air loop.