Changes in Gene Expression Associated with Macrophage Foam Cell
Formation in Mice and Humans.
Our results demonstrating that inhibition of CD36 markedly reduced LD formation imply the involvement of this scavenger receptor in foam cell
formation induced by MT-III in macrophages.
Tsurushima et al., "Triterpenoids isolated from Zizyphus jujuba inhibit foam cell
formation in macrophages," Journal of Agricultural and Food Chemistry, vol.
Caption: FIGURE 4: Infiltration of inflammatory cells including foam cells
, plasma cells, and lymphocytes ((a) x40).
Chen, "Effects of Alisma Decoction on lipid metabolism and inflammatory response are mediated through the activation of the LXRa pathway in macrophage-derived foam cells
," International Journal of Molecular Medicine, vol.
The levels of [sup.3]H-cholesterol in the liver and feces showed that [sup.3]H-cholesterol derived from macrophage foam cells
can be absorbed by the liver and eliminated from the body along with feces, thus completing the process of RCT.
Darapladib has the ability to inhibit the enzyme Lp-[pLA.sub.2], which can reduce Ox-LDL levels and number of foam cells
. It can also exhibit decreasing pattern of PVAT thickness in Sprague-Dawley rats that received HFD.
Cytokines, macrophage lipid metabolism and foam cells
: implications for cardiovascular disease therapy.
According to American Heart Association, foam cell
formation is a widely recognized phenomenon for the early lesion detection of atherosclerosis23.
Then they migrate into the subendothelial space, swallow the oxidized cholesterol, and transform it into foam cells
Focally, vacuolization of tubular epithelial cells and interstitial CD68-positive foam cells
also could be observed.
Histologic examination of CG shows cholesterol clefts surrounded by foreign body giant cells, foam cells
, macrophages and lymphocytes.