Use of chemical inhibitor decanoyl-Arg-Val-Lys-Arg-chloromethylketone (dec-RVKR-cmk) for inhibition of furin
protein convertase or inhibiting the furin
synthesis by small interfering ribonucleic acid (siRNA) results in blocking of second cleavage of the hepcidin precursor.
Thus, our study was mainly focused on the putative furin
recognition motif [sub.742][RXRR.sub.745], which is located at the basic domain of Sema3C, since furin-cleavage motif(s) present in basic domains of Sema3A and Sema3F proteins were demonstrated to play an important role in mediating their association with neuropilin receptors (NRP1 and NRP2) and to have a competitive interaction with VEGF (15,16).
Dubois, "TGFbeta1 regulates gene expression of its own converting enzyme furin
," The Journal of Clinical Investigation, vol.
GI upset was the most common ADR reported in the earlier studies by Furin
et al.,  Shin et al.,  Thomas et al.,  Vishakha and Sanjay et al.,  and Yew et al.
Pro-BDNF can be proteolytically cleaved intracellularly by enzymes (e.g., PC7, furin
, and proconvertases) and secreted as the 14kDa mature form [42, 43] or it can be secreted as pro-BDNF and subsequently cleaved extracellularly by proteases (e.g., metalloproteinases and plasmin) .
Once the target domain binds to its receptor, the immunotoxin is internalized by endocytosis, cleaved in domain II by the proprotein convertase furin
, leading to the release of the toxin and a subsequent cell killing.
Emilin-1 is known to be a binding precursor of TGF-[beta], called pro-TGF-[beta], and inhibits its maturation by furin
EVs also express genes involved in TGF-[beta] signaling (TGFB1, TGFB3, FURIN
, and ENG).
MiR24 inhibits TGF[beta]-smad2/3 signaling mediated differentiation and migration of cardiac fibroblasts by inhibiting furin
, a regulatory protein involved in latent TGF[beta] activation process.
The decrease in pH induces cleavage of prM by the host protease furin
, which leads to rearrangement of the virion surface into the herringbone-like lattice of E protein dimers of the mature virion, although the remaining portion of prM (pr peptide) still remains associated with the virion.
The pro-protein convertase (PC) PCSK9 is inactivated by furin
and/or PC5/6A: functional consequences of natural mutations and post-translational modifications.