The proprotein convertases furin
and PACE4 play a significant role in tumor progression.
N Davies, J Furin
, S Pahad, R Thom, K Thompson and N Woollett report no conflicts of interest.
Our sequence data show that serotype 1 FECV from feces of asymptomatic cats contain a highly conserved furin
cleavage motif at the S1/S2 site, with the following narrow range of residues: [(R [much less than] K/G).
57 Pipeline ADCs Using Furin
Cleavable Peptide Linker Table 5.
Cysteine Residues in the Catalytic Domain of Mammalian Furin
Form Disulfide Bonds That are Critical for Catalytic Activity.
108], which is cleaved in various amounts by corin or furin
to yield the 76 amino acid NT-proBNP and the 32 amino acid BNP (8) (Fig.
1%)], whereas in the case of coexpression with functional furin
it was significantly higher, up to 63.
Address for correspondence: Jennifer Furin
, Brigham and Women's Hospital, Division of Social Medicine and Health Inequalities, 651 Huntington Ave, 7th Floor, Boston, MA 02115, USA; email: jfurin@partners.
Purification of recombinant soluble forms of furin
produced in Chinese hamster ovary cells.
Two proprotein convertases, furin
and corin, are currently considered to be involved in proBNP processing, giving rise to distinct BNP forms: BNP (1-32) and BNP (4-32), respectively (21,22).
Human proBNP was first suggested to be cleaved bythe ubiquitous endoprotease furin
because the furin
(paired basic amino acid cleaving enzyme) (FURIN
)] and BNP ( NPPB) genes are coexpressed in cardiac myocytes (49).
The Los Angeles Memorial Coliseum is excited to host the NRFL's elite athletes in January," said Coliseum General Manager Joe Furin