A significant portion of patients do not mobilize an adequate number of stem cells with G-CSF
alone and require a second drug and more days of stem cell collection.
At least 48 h after surgery, catheterized fetuses received daily bolus infusions of G-CSF
from day 125 to day 129 of gestation.
The results of the coadministration group were significantly more than those of the BMSC and G-CSF
In the liver tissue of BMSCs, BMSCs + G-CSF
, BMSCs + JSSQ, and JSSQ groups, moderate fibrosis was found, the fibrillary space of pseudo-lobule was slender, and the degree of hepatocyte degeneration and necrosis was lighter; only a small amount of fat vacuoles was seen (Figure 4B, C, D, E).
Among the 11 cytokines evaluated over the three time-points, IL1-[beta], IL-6 and IL-10 on D7 and IL-1[beta], IL-6, IL-8, IL-10, G-CSF
on D14 exhibited AUROC values above 0.6 for predicting hospital mortality.
It has been observed that the neutrophilic response to G-CSF
was greater in neutropenic patients compared to non-neutropenic ones.18 Available local studies on use of G-CSF
in Pakistan are limited to adults and older children with febrile neutropenia or cancer.
On the other hand, studies revealed that in animals the G-CSF
and granulocyte macrophage-colony stimulating factor (GM-CSF) may mobilize endothelial progenitor cells19-20.
Having found decreased numbers of analyzed stem and progenitor cells in immunocompromised patients, we next aimed to investigate effects of G-CSF
treatment on hematopoietic stem cell mobilization in ALL patients.
Timely diagnosis and suitable treatment with G-CSF
and antibiotics are important to prevent further complication.
LPS sensitization was induced by G-CSF
pretreatment as described above .
of a high dose Cy (7 g/[m.sup.2]) regimen with G-CSF
results in a higher
Other studies have not used intrauterine G-CSF
in patients suffering from unexplained RM.