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Cells go through 3 phases before they divide: the G1 phase, in which the cell grows and makes protein; the S phase, in which the cell makes DNA and replicates its chromosomes; and the G2 phase, in which the cell prepares for division.
DNA duplication decreases but to a sufficient extent in the G2 phase to the cell cycle.
It interferes with DNA synthesis by causing single-strand DNA breaks and induces arrest of the cell division cycle at G2 phase.