regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1.
Plasma NO, GM-CSF
, VEGF, IL-6, and TNF-[alpha] Levels.
Second, statistical differences (P<0.05) were found in the serum levels of cytokines GM-CSF
, IFN-[gamma], and KC (HFD vs HFD-FR).
However, the results of studies are not consistent and a study in mice by Kong et al22 did not reveal any positive effect of G-CSF or GM-CSF
on atherosclerosis, instead it was shown by the study that G-CSF and GM-CSF
induce atherosclerosis in mice.
They found that the mice that had been given large amounts of a special cytokine - molecules that warn other cells that there's an infection or other trauma in the body - called GM-CSF
, had better survival and lung function than the other mice.
In this study, we optimized and compared the yield and purity of murine derived CD11c+ BMDCs cultured by flask culture method and CD11c Positive Selection kit based method, in the presence of low dose of GM-CSF
in nontreated tissue culture flasks.
Herein, we assessed cytokines and growth factors crucial for eosinophil proliferation and differentiation (GM-CSF
, IL5, and IL4), for their release from bone marrow (IL5), for their survival (IL5, IL13, GM-CSF
, and IL4) and priming in circulation (IL5, GM-CSF
, IL4, and TNF[alpha]), and for extravasation (IL4, IFN[gamma], TNF[alpha], IL8, and eotaxin) and homing into the gut (eotaxin, RANTES, IL5, IL8, IL13, GM-CSF
, and TNF[alpha]) as well as responsible for inducing production and secretion of their mediators (TNF[alpha], IFN[gamma], IL-5, GM-CSF
, and eotaxin) (reviewed in [10, 17, 20]).
AGEs Enhanced Expression of Proinflammatory Cytokines and GM-CSF
in Monocytes In Vitro.
Blood sample was tested for antibodies against granulocyte macrophage-colony stimulating factor (GM-CSF
) through an outside lab and was reported negative.
Granulocyte macrophage colony stimulating factor (GM-CSF
) also contributes to the enhancement of COPD through increasing the number of neutrophils [26, 27].
In addition, EPC is regulated by cytokine such as NO, VEGF, GM-CSF
, IL-8, and MCP-1 as well [15-20].
In RA, cytokines such as tumor necrosis factor alpha (TNF-[alpha]), interleukin-6 (IL-6), IL-17a, IL-22, IL-23, IL-1[beta], IL-8, interferon-y (IFN-[gamma]), granulocyte/macrophage colony-stimulating factor (GM-CSF
), granulocyte colony stimulating factor (G-CSF), IL-15, IL-18, IL-33, and IL-37 [11, 13, 18-36] are all detected either in the serum or in the synovial fluids of these patients.