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Related to Gain of function: genetic mutation, mutation, Conditional mutation, Loss of function

MUTATION, French law. This term is synonymous with change, and is particularly applied to designate the change which takes place in the property of a thing in its transmission from one person to another; permutation therefore happens when, the owner of the thing sells, exchanges or gives it. It is nearly synonymous with transfer. (q.v.) Merl. Repert. h.t.

References in periodicals archive ?
7 gain of function mutation in approximately 30% of idiopathic Small Fiber Neuropathy[sup.
After the ROSA26 locus was developed as a knock-in site for gain of function, many types of mouse lines were developed and the followings are some examples as representatives on various settings.
Therefore the diagnosis was pseudo (platelet type) vWD which is a rare disorder arising from a gain of function mutation in the gene for the platelet glycoprotein-1b receptor (GP1BA).
Researchers believe that the CAG repeats involved in these neurodegenerative diseases provide a gain of function, in contrast to the apparent loss of function in fragile X.
In a poster session Sunday, April 18, "Cancer-associated IDH1 mutations produce 2-hydroxyglutarate," Agios scientists demonstrated that the mutated IDH1 gene has a novel gain of function enzyme activity consistent with a cancer-causing gene, or oncogene.