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1968; Ohno, 1970), an expanding volume of studies has examined the evolutionary consequences of gene duplication (reviewed by Innan and Kondrashov, 2010; Kondrashov, 2012; Canestro et al.
Baumann et al (l9) described a depressed patient with CYP2D6 gene duplication who required higher-than-usual doses of clomipramine.
These include insertion of repeat sequences, change in expression profile, gene duplication, gene fusion and gene loss or inactivation (9).
About 1,200 different protein domains are known; they are used in many different combinations, thus defining many gene families that developed through gene duplication.
cynomolgi SSU rRNA genes has indicated that the genes appear to have evolved as a result of 2 gene duplication events (10).
Gene duplication event in family 12 glycosyl hydrolase from Phytophthora spp.
Results also supported the theory of genome evolution by partial gene duplication.
Gene duplication in 1 allele was later confirmed by the finding that 17-OH progesterone concentrations were within the reference interval in the amniotic fluid and by fetal echography showing ordinary female external genitalia.
The Sad2 gene has evolved from the most ancient and highly conserved cytochrome P450 family by gene duplication and then diverged from its original role in making sterols to adopt a new function producing an antimicrobial chemical called avenacin.
In one daughter lineage, gene duplication and selection achieved a new balance to develop a complex organ like an eye out of that inherent potential.