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A new and interesting feature of our genotyping protocol is the possibility of determining the phase of gene duplication.
In the complementary XbaI RFLP analysis, all carriers of gene duplications had the 42-kb band characteristic of CYP2D6 gene duplication (15), indicating a full association between the mutations that induce the presence of the 12.
A possible explanation is that the *4 allele in this case contained a gene duplication.
We also developed an alternative method to detect gene deletion and duplication based on non-sequence-specific detection of PCR products by the DNA binding dye SYBR Green in combination with the designated pairs of primers for the detection of gene deletion and gene duplication (15).
In addition, the pedigree of family A revealed a CYP2D6*35x2 gene duplication.
Structure and genetics of the partially duplicated gene RP located immediately upstream of the complement C4A and the C48 genes in the HLA class III region: molecular cloning, exon-intron structure, composition retroposon and breakpoint of gene duplication.
for question 182, superoxide anion is not only detoxified by superoxide dismutase but also by catalase and glutathione peroxidase, and for question 179, increased cytochrome P450 activity results from gene duplication or stimulation of a preexisting enzyme by a xenobiotic).
For detection of the CYP2D6X2 gene duplication, two 25-[micro]L long-PCR reactions were performed as described previously (31).
The occurrence of gene duplication varies widely, from 29% in Ethiopians (7), to 20% in Saudi Arabians (8), to 1-7% in Caucasians (9, 10), to 1-2% in Orientals (11-13), although not many data are available for the latter.
This means that the early consequences of gene duplication, and the early divergence of duplicated genes, have not been studied on a genomic scale.
The role of VAMP7 gene duplication in causing these male birth defects was important because of the type of protein family it belongs to - it is a SNARE (Soluble N-ethylmaleimide-sensitive factor activating protein receptor) protein (a large protein superfamily consisting of more than 60 members in yeast and mammalian cell), Lamb said.