The major cell type in the carotid body is type-I glomus cells
, which are chemosensitive and responsive to chemical changes in the arterial blood.
They have been subcategorized as solid (75% of cases), glomuvenous malformation (glomangioma), and glomangiomyoma, depending on the relative prominence of glomus cells
, vascular structures, and smooth muscle.
Smooth muscle fibers were seen as large bundles and focally were intimately associated with the glomus cells
The excision biopsy was consistent with glomangioma that showed thin walled vascular spaces surrounded by one or few layers of glomus cells
. This glomus cells
are characterized by abundant pink or pale cytoplasm and oval or round central nuclei.
Perivascular myomas exhibit a broad histologic spectrum, from hemangiopericytoma-like or glomus tumor-like to angioleiomyoma-like, and it is speculated that they differentiate along the lines of smooth muscle, pericytic, and glomus cells
. Immunohistochemically, perivascular myomas are stained frequently with anti-actin antibodies and rarely with anti-desmin antibodies, according to their degree of cellular differentiation.
Histopathology report on routine haematoxylin and eosin stain came as thin intact fibrous capsule surrounding the tumor composed of varying population of glomus cells
(monotonous round cells with pale eosinophilic cytoplasm with well-defined cell borders with occasional spindle shaped cells and mast cells; large central round or oval punched out chromatin, uniform nucleus and scanty cytoplasm) with tortuous vascular spaces containing blood and lined with endothelium scattered between the tumor cells.
Glomangioma (glomus tumor): Is an uncommon true benign tumor arising from contractile glomus cells
that are present in the arterio venous shunts.