Overexpression of miR-21 in stem cells improves ovarian structure and function in rats with chemotherapy-induced ovarian damage by targeting PDCD4 and PTEN to inhibit granulosa cell
Hypertrophy of granulosa cells
were clearly detected (Fig.
This is one of the best known ovarian tumors and has taken its place in their classification system for decades now but ironically, at least in my opinion, is a rare tumor that has received perhaps disproportionate interest in the literature in part because of its being 1 of the 2 often estrogenic neoplasms of the ovary, the other being the granulosa cell
Expression of members of the bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell
apoptosis is associated with decreased bax and constitutive bcl-2 and bcl-xlong messenger ribonucleic acid levels.
were cultured with the same method for hormonal measurement.
In the present study, anethole at a dose of 30 [micro]g/mL more effectively stimulated granulosa cell
proliferation; furthermore, it also promoted greater follicular diameter.
Kim et al., "Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell
tumors of the ovary," Gynecologic Oncology, vol.
One of our recent studies also demonstrated that visfatin was more expressed in the theca than in granulosa cells
in turkeys  and that its plasma level was higher at the end of the laying period compared to the beginning.
In cattle, batches of miRNAs are present in the ovary (Hossain et al., 2009), and miRNAs demonstrate spatio-temporal expression in oocytes, granulosa cells
(GCs), cumulus cells, and preimplantation embryos (Abd El Naby et al., 2013).
This was presumably because androgens targeted granulosa cells
where they initiated follicular growth and maturation and enhanced the number of follicles at various other stages of development.
The high expression of TNF-[alpha] in rats, In addition induction of apoptosis in granulosa cells
of antral follicles, mitogenic theca interstitial cells stimulating activities and increasing the number of steroidogenic cells, cause progress of PCOS.